As Labor Day weekend approaches, I want to take a moment to celebrate the many workers who contribute to science every day, in ways that often go unacknowledged. To those who spend their days measuring, mixing, pipetting, and more at the laboratory bench; to those who enter and crunch the data; to those who passage the cultures and mind the stocks; to those who feed and care for all the creatures we call “model organisms;” to those who order supplies, handle schedules and correspondence and travel arrangements; to those who process grant applications, edit manuscripts and account for the funds; and everyone else who works hard to keep the enterprise we call genetics moving forward: Happy Labor Day!